Expression of neurotrophic factors by Schwann Cells promotes regeneration of central nervous system
Schwann cells (SCs) are glial cells originally found in the peripheral nervous system. These cells express many neurotrophic factors, which have many implications on neuronal survival and regeneration, and present receptors to some of these factors suggesting autocrine stimulation to SCs survival, proliferation, differentiation and development. Some of these factors are expressed naturally while others need a traumatic situation and/or axonal contact. The secretion of factors has an important function as mediator of neuron-glial signaling. Many expressions of factors are suppressed in SCs of intact nerves but axonal injury promotes increasing of their synthesis and, yet, production of these factors is suppressed during nerve regeneration. The purpose of this article is to review key studies showing that intracerebral SC grafts limit injury-induced tissue loss and promote axonal regeneration and myelination and that this response can be improved by adding neurotrophic factors. Finally, this review will reflect on the prospect of SCs for repairing the nervous system.
Authors must declare that the work submitted is their own and that copyright has not been breached in seeking its publication. If the manuscript includes work previously published elsewhere, it is the author(s) responsibility to obtain permission to use it and to indicate that such permission has been granted.
If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email requesting them to complete the license agreement on behalf of all authors on the paper.