Exercise and pharmacological treatment: influence on locomotor activity in SHR rats

Nádia Esteves dos Santos; Camila Aparecida Sansão Coelho; Milca Abda de Morais; Beatriz da Silva Franco; Andrea Maculano Esteves

doi:10.20338/bjmb.v13i1.123

Exercise and pharmacological treatment: influence on locomotor activity in SHR rats

Authors

Nádia Esteves dos Santos Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas, SP, Brazil
Camila Aparecida Sansão Coelho Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas, SP, Brazil
Milca Abda de Morais Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas, SP, Brazil
Beatriz da Silva Franco Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas, SP, Brazil
Andrea Maculano Esteves Faculdade de Ciências Aplicadas da Universidade Estadual de Campinas, SP, Brazil - andrea.esteves@fca.unicamp.br

DOI:

https://doi.org/10.20338/bjmb.v13i1.123

Keywords:

aerobic, augmentation, pramipexole, restless legs syndrome

Abstract

Restless legs syndrome (RLS) is characterized by abnormal sensations in the lower limbs and negatively impacts on sleep. Dopaminergic agonists (pramipexole, PPX) may be used in the treatment. However, chronic use may cause worsening of symptoms (augmentation). Physical exercise (PE) also may be effective in reducing RLS symptoms and improving the sleep pattern. The main purpose of this study was to evaluate the effect of PPX and acute PE on locomotor activity (RLS symptoms) of spontaneously hypertensive rats (SHR). Animals were distributed into 4 groups: Saline, PPX1 (0.1 mg/kg) at 75 days of age, PPX2 (0.05 mg/kg) at 91 days of age and PPX3 (0.05 mg/kg) at 125 days of age.The animals received a daily injection of PPX or saline (07:00 h) for 48 days. The PE (treadmill) consisted of a single session (30 min) at 20–22 m/min. The evaluation of locomotor activity (open field) was performed at baseline and weekly, after administration of the drug. Both PPX and PE caused changes in locomotor activity (RLS symptoms), on specific days. The groups that received PPX had weight changes when compared with the saline groups, but without manifestation of the augmentation.

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Published

2019-05-01

How to Cite

dos Santos, N. E., Coelho, C. A. S., de Morais, M. A., Franco, B. da S., & Esteves, A. M. (2019). Exercise and pharmacological treatment: influence on locomotor activity in SHR rats. Brazilian Journal of Motor Behavior, 13(1), 23–31. https://doi.org/10.20338/bjmb.v13i1.123

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Issue

Vol. 13 No. 1 (2019)

Section

Research Articles

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