Exercise and pharmacological treatment: influence on locomotor activity in SHR rats
Restless legs syndrome (RLS) is characterized by abnormal sensations in the lower limbs and negatively impacts on sleep. Dopaminergic agonists (pramipexole, PPX) may be used in the treatment. However, chronic use may cause worsening of symptoms (augmentation). Physical exercise (PE) also may be effective in reducing RLS symptoms and improving the sleep pattern. The main purpose of this study was to evaluate the effect of PPX and acute PE on locomotor activity (RLS symptoms) of spontaneously hypertensive rats (SHR). Animals were distributed into 4 groups: Saline, PPX1 (0.1 mg/kg) at 75 days of age, PPX2 (0.05 mg/kg) at 91 days of age and PPX3 (0.05 mg/kg) at 125 days of age.The animals received a daily injection of PPX or saline (07:00 h) for 48 days. The PE (treadmill) consisted of a single session (30 min) at 20–22 m/min. The evaluation of locomotor activity (open field) was performed at baseline and weekly, after administration of the drug. Both PPX and PE caused changes in locomotor activity (RLS symptoms), on specific days. The groups that received PPX had weight changes when compared with the saline groups, but without manifestation of the augmentation.
Authors must declare that the work submitted is their own and that copyright has not been breached in seeking its publication. If the manuscript includes work previously published elsewhere, it is the author(s) responsibility to obtain permission to use it and to indicate that such permission has been granted.
If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email requesting them to complete the license agreement on behalf of all authors on the paper.